结果冠心病组血清内脂素、高敏C反应蛋白水平显著高于正常对照组(P<0.05);血清内脂素、高敏C反应蛋白水平急性心肌梗死组显著高于不稳定型心绞痛组(P<0.05),不稳定型心绞痛组显著高于稳定型心绞痛组(P<0.05);血清内脂素与高敏C反应蛋白水平无明显相关性(P>0.05);多支病变组与单支病变组内脂素水平差异无显著性(P>0.05),而多支病变组高敏C反应蛋白显著高于单支或病变组(P<0.05)。结论内脂素和高敏C反应蛋白在预测冠心病中有重要价值,它们在冠心病外周血中浓度的升高可以提示冠状动脉粥样斑块的不稳定,但两者无相关性;高敏C反应蛋白在预测冠状动脉病变程度方面有一定作用,但还不能以内脂素作为预测冠状动脉病变程度的指标。"
“【目的】研究数均分子量为0.1×105～3.0×105(组分1)及1.8×103(组分2)Selleck的西藏灵菇胞外多糖组分对正常小鼠免疫功能的影响,并探讨其影响机制。【方法】依据卫生部保健食品功能学评价程序和检验方法,灌胃给药,剂量分别120mg/kg体重、80mg/kg体重、40mg/kg体重,检测脏器/体重比值、半数溶血值(HC50)、自然杀伤细胞(NK)活性、迟发型变态反应(DTH)、腹腔巨噬细胞吞噬功能。采用免疫印迹法,测定小鼠腹腔巨噬细胞中{Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|Selleck Anti-infection Compound Library|Selleck Antiinfection Compound Library|selleck Anti-infection Compound Library|selleck Antiinfection Compound Library|selleck Anti-infection Compound Library|selleck Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|Anti-infection Compound Library|Antiinfection Compound Library|购买Anti-infection Compound Library|Anti-infection Compound Library半抑制浓度|Anti-infection Compound Library价格|Anti-infection Compound Library花费|Anti-infection Compound LibraryDMSO溶解度|Anti-infection Compound Library购买|Anti-infection Compound Library生产商|Anti-infection Compound Library查找购买|Anti-infection Compound Library订单|Anti-infection Compound Library mouse|Anti-infection Compound Library化学结构|Anti-infection Compound Library分子量|Anti-infection Compound Library molecular weight|Anti-infection Compound Library说明书|Anti-infection Compound Library supplier|Anti-infection Compound Library体外|Anti-infection Compound Library细胞系|Anti-infection Compound Library concentration|Anti-infection Compound Library NMR|Anti-infection Compound Library体内|Anti-infection Compound Library临床试验|Anti-infection Compound Library cell assay|Anti-infection Compound Library screening|Anti-infection Compound Library high throughput|购买Antiinfection Compound Library|Antiinfection Compound Library半抑制浓度|Antiinfection Compound Library价格|Antiinfection Compound Library花费|Antiinfection Compound LibraryDMSO溶解度|Antiinfection Compound Library购买|Antiinfection Compound Library生产商|Antiinfection Compound Library查找购买|Antiinfection Compound Library订单|Antiinfection Compound Library化学结构|Antiinfection Compound Library说明书|Antiinfection Compound Library supplier|Antiinfection Compound Library体外|Antiinfection Compound Library细胞系|Antiinfection Compound Library concentration|Antiinfection Compound Library临床试验|Antiinfection Compound Library cell assay|Antiinfection Compound Library screening|Antiinfection Compound Library high throughput|Anti-infection Compound high throughput screening|Erk蛋白及COX-2酶的表达量。【结果】组分1能够明显提高HC50,NK细胞活性以及DTH,且量效关系体现为低剂量效果好于高剂量;组分2能够明显提高DTH、巨噬细胞吞噬率和吞噬指数,其量效关系体现为高剂量效果好于低剂量。Erk蛋白和COX-2酶表达量的趋势与吞噬指数的变化趋势相同。【结论】组分1、组分2均具有调节正常小鼠免疫功能的作用,组分1的调节免疫作用主要通过NK细胞、B细胞来实现,而组分2主要通过巨噬细胞和T细胞来实现。